EFFECT OF IMMUNOSUPPRESSION IN VITRO INTERLEUKIN 1B ON CELLS CORTICOTROPAS OF THE PITUITARY GLANDAuthor:
MONTERO HERNANDEZ MARIA DEL CARMEN.
Year:
2004.
University:
SALAMANCA [
www.usal.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: FACULTAD DE MEDICINA.
Summary: Since the IL-1 is synthesized in the pituitary gland, is involved in regulating the secretion of the hormone ACTH, and in other tissues, exerts a regulatory action of cell proliferation and apoptosis, a study of the effects of IL-1 on the proliferation and apoptosis of cells producing pituitary ACTH and is related to the effects of other regulators as Arg-vasopresina and glucocorticoids. Different results suggest that IL-1 in in vitro studies conducted is an important regulator paracrino the functionality of cells producing pituitary ACTH. The regulation on the local population producing pituitary ACTH, IL-1 is involved in this mechanism through the modulation of cell proliferation and apoptosis. The effects of IL-1 on the cells producing pituitary ACTH are harnessed by the Arg-vasopresina, except when it comes to apoptosis of these cells. The corticosterona and, by extrapolation, glucocorticoids, blocks the effects of IL-1 on the cells producing pituitary ACTH. Glucocorticoids blocking the effects of Arg-vasopresina on cells producing pituitary ACTH. Glucocorticoids predominate on the IL-1 and Arg-vasopresina in the regulation of apoptosis, but not the proliferation of cells producing pituitary ACTH.
