ALLERGIES

Author: RODRÍGUEZ RODRIGUEZ JULIA.
Year: 2004.
University: COMPLUTENSE DE MADRID [www.ucm.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: UNIVERSIDAD COMPLUTENSE. FACULTAD DE MEDICINA.

Summary: The diagnostic evaluation of 283 adult patients referred racciones adverse food through clinical questionnaire, pruevas skin, certification of specific serum IgE and oral provocation food double-blind controlled placedo, has identified 101 patients with allergy clinic alimentos.Los Frequently agents have been fruit, especially peaches and melón.Los symptoms of the reactions were polarized between oral allergy syndrome and systemic reactions graves.Se have defindo as major allergens of melon and profilina and a protein PR-1 . For other foods such as beer, has been documented as an allergen protein Z LTP and the cross-reactivity cebada.La clinic has been investigated in fruit roséceas, with its relevance in 43% of patients allergic to melocotón.En the group of pulses, chickpea presented allergic reactions associated with lentil not going well with the peanut, not relacojnado clinically with food from this group, sono with other fruits secos.En The present study has identified that the relevancy clinic of the immunological cross-reactivity between food from the same group has to be evaluated by oral provocation, have been investigated food causes of occupational asthma and rhinitis by inhalation in the workplace, docuemntándose fish oil, asparagus, ginger and lupine as agents causantes.Asimismo, through review articles have attempted to redefine the state of knowledge of food allergy in adults, both for clinical practice, for the consumer and the food industry.

Author: FERRER TORRES ÁNGEL.
Year: 2004.
University: MIGUEL HERNÁNDEZ DE ELCHE [www.umh.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: FACULTAD DE MEDICINA, UNIVERSIDAD MIGUEL HERNANDEZ.

Summary: Are some 16 species of mites living in the mattress of houses located on the coast and the interior of the province of Alicante. An estimated abundances the population and the diversity of mites responsible for alérgias and compares the data between those found in the houses on the coast and the interior, between the mattresses obtained in patients with symptoms of allergic and non-allergic people . It was calculated and compared (between the coast and the interior, between allergic and non-allergic patients) levels of allergen-specific Dermatophagoides and other mites. It has been found in patients allergic IgE for each of the species Pyriglyphidae (D. pteronyssinus, D. farinae and E. maynei) and other Astigmata and compares porcentages awareness obtained in vitro and in vivo. It explores and establishes the degree of cross-reactivity between the different species of mites associated with the mattress. By prubas provocative nose, skin tests and identification of in vitro IgE, it exposes the clinical implication of mites living in mattresses and in particular that of D. Pteronyssinus in asthmatic disease.

Author: MILLER GUERRERO MIGUEL.
Year: 2005.
University: SEVILLA [www.us.es].
Place of defense: FACULTAD DE MEDICINA DE SEVILLA.
Place of preparation: FACULTAD DE MEDICINA DE SEVILLA.

Summary: After antigenic recognition, the T lymphocyte is activated, releasing interleukin 2 (IL-2) and increased expression of the receptor interleukin 2 (IL-2R) on its surface. The binding of IL-2 to IL-2R stimulates cell proliferation and the release of a fraction of IL-2R, receiver soluble interleukin 2 (sIL-2R), T lymphocyte activation marker Our goal was to determine the usefulness of sIL-2R as exposure settings and tolerance in patients allergic allergic asthmatics. We determine the levels of sIL-2R in the supernatant culture peripheral blood mononuclear cells stimulated with phytohaemagglutinin. We select different groups: healthy individuals, asthmatic patients allergic to grass pollen not immunized, and immunized for 3 years with different patterns of immunotherapy (preestacional and coestacional). The sIL-2R was measured before the pollen season (no allergen exposure) and during the pollen season, the spring (with the natural allergen exposure). In the asthmatic group there was an increase in levels of sIL-2R in spring (this increase does not occur in a healthy group), differences with the group's healthy in the spring but not before that. We conclude that the sIL-2R is an allergic exposure settings. In the group with immunotherapy coestacional did not find significant differences in the production of sIL-2R measure in the two times, with similar levels in the healthy group both times. In the group with immunotherapy preestacional there is an increase in levels during the pollen season. We conclude that immunotherapy coestacional shown as a factor inhibiting the production of sIL-2R during exposure to the specific allergen, inducing a normalization of the values of sIL-2R during the pollen season, the preestacional would. Determining levels sIL-2R measured in the supernatant of cultured cells could serve as a useful marker of the effectiveness of immunotherapy in patients allergic asthmatics. We wanted to reproduce in the laboratory the findings in the exhibition naturally. To do this we select 4 groups of asthmatic patients sensitive to grass pollen not hiposensibilizados, who were exposed to various bronchial provocation, by measuring levels of sIL-2R before and after provocation. The specific bronchial provocation induced greater production sIL-2R after provocation. When the cause specifically on different days, at doses that do not produce bronchoconstriction (priming), there was also a greater production of sIL-2R the fifth day, before the provocation. The nonspecific bronchial provocation with metacholine or an allergen that were not sensitive (D pteronyssinus) not resulted in a greater production of sIL-2R, confirming that the sIL-2R is a specific marker of exposure (both natural and experimental) and not bronchial hyperreactivity. Finally, we divided the patients caused specifically depending on the type of response that submitted (immediate and dual). These patients conducted by questionnaire, a symptom scores and use of medication beta 2 inhaled short acting rescue during the pollen season. Patients who had a dual response produced more quantity sIL-2R after specific bronchial provocation, had more symptoms and greater use of rescue medication than those who had only an immediate response. In both groups there was a correlation between the use of rescue medications and symptoms. Only in the group of dual there was a correlation between the levels of sIL-2R measured after bronchial provocation and the amount of medication used and between these levels and 8 the Sinto 359 matología. The correlation between the levels of sIL-2R and depends on the symptoms the patient has an answer in its dual bronchial provocation.

Author: VILLANUEVA TRIGUERO JUAN CARLOS.
Year: 2005.
University: MIGUEL HERNÁNDEZ DE ELCHE [www.umh.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: FACULTAD DE MEDICINA. CAMPUS UNIVERSITARIO DE SANT JOAN D ALACANT.

Summary: Allergic rhinitis is a disease of high prevalence, a 10-15% in the general population, with multiple triggers. We know the importance of the consumption of cow's milk as a provocateur of allergic reactions in patients with food allergy to components of cow's milk. What is not shown, is its influence on the onset of episodes of allergic rhinitis without allergy to cow's milk as food. OBJECTIVES: Index: To check the influence of the consumption of cow's milk in patients without this food allergy, the emergence of episodiosde allergic rhinitis. Secondary: Identify the frequency of symptoms associated with allergic rhinitis, atopic dermatitis and asthma. PATIENTS AND METHODS: We use an intervention study, open and controlled randomization of patients diagnosed with allergic rhinitis through skin test, and did not submit food allergy to cow's milk. The intervention consists of the restriction of dietary cow's milk. RESULTS: We assessed 70 (35 in the control group and 35 in the intervention group). At the start of the study, both groups were comparable. In relation to the main goal, after a year of follow-up, completing the study 32 patients in the GC and 31 of GI, introducing episodes of allergic rhinitis, a 57.14% of the patients in the GC and 2.85% of the GI (CI 95% of the difference of 0.54 + /-, - 0.17 and p 0.01 S CONCLUSIONS: avoiding consumption of cow's milk in the diet of patients with allergic rhinitis, food allergy, get diminish the frequency of episodes of allergic rhinitis and its associated symptoms. also reduces the frequency of crises atopic dermatitis. does not show influence in terms of the evolution of asthma in the study period.

Author: JUSTICIA RUANO JOSÉ LUIS.
Year: 2005.
University: GRANADA [www.ugr.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: FACULTAD DE MEDICINA.

Summary: OBJECTIVE determine what factors are associated with an increased risk of systemic reactions (RS) for immunotherapy alérgeno-específica (ITE), and build them with a clinical prediction model, allowing the stratification of patients according to their risk. PATIENTS AND METHODS observational study, prospective, in which, for 7 years (1996 to 2002) were recorded RS patients receiving ITE group to treat his respiratory allergies caused by pollen from the olive tree or grass. Through simple logistic regression, we determined the association between RS and patient-related variables (gender, age, disease severity, years of evolution, ITE prior symptoms extraprimaverales, prick-test, sensitization to other allergens, total IgE, specific IgE ), with the pattern, with the extract composition, batch) and the environment (year administration, quarter, county and habitat). As variables were selected those candidates who achieved a level of significance alpha smaller 0.30. The final model was constructed using multiple logistic regression, remaining variables with significance level less 0.05. RESULTS Of the 611 selected patients, 65 (10.6%) had RS. Of all the variables analyzed, only 7 remained in the final model: older age 14 years (OR = 0.3), awareness quenopodiáceas (OR = 3.0), IgE-Olivo elevated (OR) = 4.1), IgE-Gramíneas elevated (OR = 2.3), composition Ilivo 100% (OR = 2.6) and pattern (OR = 1.6 to 7.1, depending on the pattern). CONCLUSIONS With variable clíncias easily identifiable, it has developed a predictive model that is used to calculate the risk of systemic reactions in advance by inmunoterpaia (from 0.3% to 84.3%). The detection of those patients at higher risk of intervention, action may be taken to prevent systemic reactions.

Author: LÓPEZ CERES ANA.
Year: 2005.
University: MÁLAGA [www.uma.es].
Place of defense: FACULTAD DE MEDICINA.
Place of preparation: FACULTAD DE MEDICINA.

Summary: The mucosal squamous cell carcinoma of the oral cavity is about 3% of all malignancies in the body. The thickness of the tumor in squamous cell carcinoma of the oral mucosa is not a prognostic factor used in the practice, despite having been mentioned frequently is in the literature and that is a prognostic parameter in some prominent neoplasia (especially melanoma skin ). The general hypothesis of this research is the relationship between tumor thickness in the mucosal dela epidermoid carcinoma of the oral cavity and the local presence of metastases at diagnosis and their relationship to survival. To this end, we conducted a retrospective study on a wide range of patients, from Complex Carlos Haya Hospital in Malaga, diagnosed with squamous cell carcinoma of the oral cavity mucous and intervened in the Service of Oral and Maxillofacial Surgery, for 5 years (1998 -2003). Epidermoid carcinoma of the oral mucosa, in our environment, is more prevalent in males. With an average age of 61 years, usually located in the language and tumor diameter means of 123.26 mm., And thickness of 8.99 mm. The relationship between tumor thickness (macro and evaluated microscopically) and the size of the lesion T showed a statistically significant correlation. The presence of lymph nodes at the time of diagnosis has been associated with increased tumor size and thickness. Overall survival of patients to 7 years old is 42%. When the tumor thickness is less than 7mm., Survival improved dramatically reaching 70%. When the tumor thickness is less than 7mm., And no lymph node involvement survival to 7 years old is 80% and if they lymph node involvement survival to 7 years old is 36%.

Author: RICO DÍAZ MARÍA DE LOS ANGELES.
Year: 2006.
University: A CORUÑA [www.udc.es].
Place of defense: FACULTAD DE CIENCIAS DE LA SALUD.
Place of preparation: FACULTAD DE CIENCIAS DE LA SALUD.

Summary: The shellfish, mollusks and crustaceans, are part of the usual diet of our community. They are composed of proteins with a high potential alergéncio and can be the cause of allergic reactions. We know that tropomiosina is the largest shellfish allergen and is a panalergeno among invertebrates. It is suspected that, as happens with food of plant origin, raising awareness of the seafood may be in some cases secondary to a primary awareness to aeroalergenos as mites, as they contain tropomiosina showing great homology with the tropomiosina of seafood. We do not know the exact prevalence of seafood allergy in Galicia, or potential risk factors for such awareness. OBJECTIVES epidemiological study, clinical awareness allergic to the different species of seafood among patients Area health of A Coruna attending the consultations service Allergy at the University Hospital Juan Canalejo of A Coruna. Addressing the possible risk factors such awareness to compare different variables associated in this group of patients who are sensitive to shellfish compared to a control group. MATERIALS AND METHODS During the study period 1992-2000 were attended 11921 patients of whom were included in the study group of 108 patients who were diagnosed with allergic sensitization seafood. It also selected a control group of 108 patients. Data were collected demographic and clinical. The study conducted allergic to both groups was: Evidence skin prick method according to aeroalergenos, mosquitoes and cockroaches, and seafood: shrimp, fiddler crab, lobster, percebe, clam, mussels, octopus, squid, sea shell, and other foods: fish and anisakis; determination of serum total IgE and IgE specifies (Immunocap Pharmacia diagnostics); challenge oral controlled openly with the seafood eaten suspects in the manner that had caused the reaction. Statistical analysis was performed using the following tests: chi-square test, odds ratio 95% CI, Kappa coefficients, Kolmogorov-Smirnov test, test T studente, logistic regression models. Values significant p less 0.05 Program statistics SPSS Inc. 12.0. Results The prevalence of allergic sensitization seafood in the sample studied: 0.9% the average age in the diagnosis: 26.4 + - 13.4 years. The latent period of the symptoms was less than 1 hour in the 97% and 93% had a history of more than two adverse reactions with seafood. The 62% of patients had filed only reaction with crustaceans, 3.4% with shellfish and 34% with both. Among the species of crustaceans was more common prawn and percebe. Among shellfish, first cephalopods (octopus) and between bivalves, clams. The 63% of patients had symptoms of severe intensity being the most common symptoms of skin (96%) (oral allergy syndrome: 55%, contact urticaria 31%) breathing (62%) digestive 18% and anafilácticos 12%. In terms of exposure pathways in addition to the digestive track the 79% related symptoms by contact and 50% by inhaling fumes from cooking. The frequency and relative risk of reacting to another kind of seafood among patients who had already responded to a kind of shellfish was increased significantly, to kind of seafood among patients who had already responded to a kind of seafood was higher so significant species in the same edge but not for different species of edges. The 98% of patients who are sensitive to shellfish were atopic, sensitive to mites 98%, 83% sensitized to cockroach the 37% to anisakis s. Of the 108 patients, 70% had filed more than two reactions with the same species of shellfish and among these, 26% showed a tolerance dose sub-thresholds of the species guilty. We found that the case-control study, patients sensitized to the shellfish had a significant association with the presence of atopy, sensitization to mites, cockroaches, mosquitoes and anisakis in relation to the control group 8 and that 2d4 plicata a regression model logistics, it was independent of age and sex. The 20% of patients in the control group showed a positive skin test for any kind of seafood, which had no awareness expressiveness clinic, all of which were in turn are sensitive to mites and cockroaches.