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HUMAN PARASITOLOGY

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6 theses in 1 pages: 1
  • EPIDEMIOLOGY OF SWINE ASCARIOSIS IN EXTREMADURA

    Author: SANCHEZ MURILLO JOSÉ MARÍN.
    Year: 2002.
    University: EXTREMADURA [More theses of this university] [www.unex.es].
    Place of preparation: FACULTAD DE VETERINARIA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#107778
    Summary: The Iberian pig is an animal perfectly adapted to the harsh environmental conditions of the dehesa. However, we must not forget that the role of parasitic processes is generally much sharper in the holdings of an extended or semiextensivo by the greater difficulty of controlling some of the parasitic stages. In this paper, and using the ELISA technique, has done an epidemiological study on the natural infestation by Ascaris suum the Iberian pig exploded in extensividad in the Extremadura region. They have analyzed a total of 5,060 serum blood Iberian pig, of which 1,988 pertencieron at age recrío, 2,614 animals of bait and 458 to players. It established two cut points, in 20% and 40%, whereas as those negative sera obtaining values below 20%, and positive values which derive over 40%. The group of sera with reactividades between 20 and 40% were described as dubious or weak positive. The number of sera with values below 20%, ie values clearly negative was 3,678 (73%). Those sera with reactividades between 20 and 40%, were a total of 494 (10%). Serums more reactive, with percentages above 40%, or serums for animals clearly positive, were a total of 891 (17%). Regarding the seroprevalence obtained, the highest possessing breeding animals and age bait, and depending on the diagnosis limit elected, the results age for the region of Extremadura, are pinned between a 17.6 and 27, 3%. The lowest figure on record corresponds to recrío (7.4-14.3), followed very far, data from the bait (23.8-35.0) and reproductors (26,4-40,2 ). By provinces, regarding the reactivida average sera, the value obtained in the province of Badajoz (13.7) is clearly superior to that obtained in the province of Caceres, whose average EIA% for total serum remains at levels very close to the negative control (1.0). The analysis, by farms, considering positive, those in the less an animal has been diagnosed with reactivity exceeding 40%, reveals that more than half of them have shown positive, 55% of those studied.
  • VISCERAL LEISHMANIASIS IN THE GOLD STANDARD: VALUATION OF NEW FORMULATIONS OF AMPHOTERICIN B.

    Author: RAMA IÑIGUEZ SARA.
    Year: 2003.
    University: COMPLUTENSE DE MADRID [More theses of this university] [www.ucm.es].
    Place of defense: FACULTAD DE FARMACIA.
    Place of preparation: FACULTAD DE FARMACIA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#107604
    Summary: This thesis is in the valuation of new formulations of amphotericin B compared with visceral leishmaniasis caused by L.infantum.Para it first has established a suitable animal model, which has helped set the optimal conditions for their application to our objetivos.Posteriormente, have tried different treatment regimens, different states of mind, aggregation of amphotericin B, various polymer encapsulation and various doses of active ingredient, valorándose effectiveness parsitológica, and the humoral and cellular immune response by conducting follow developments the treatment level immune. Of all the formulations tested proved to be the best of the human albumin séria containing amphotericin B in a state poliagregado, since there was a high efficiency, with no toxic effects and decreased levels of antibodies, the immune and renal recovery dela cell proliferation. In addition, efforts are on the verge of molecular biology techniques for the determination of immunological parameter as expresiónn cytokine in approach and to tally the parasites in organs.
  • STRUCTURE AND FUNCTION OF PROTEINS CONSERVED IN TRIPANOSOMATIDOS. INVOLVEMENT IN CELL DEATH

    Author: NGUEWA TCHINDA PAUL ALAIN.
    Year: 2005.
    University: LA LAGUNA [More theses of this university] [www.ull.es].
    Place of defense: FACULTAD DE FARMACIA.
    Place of preparation: FACULTAD DE FARMACIA, DEPARTAMENTO DE PARASITOLOGÍA, ECOLOGÍA Y GENÉTICA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#110856
    Summary: This thesis demonstrates for the first time the existence of programmed cell death (PCD) in Leishmania braziliensis and establishes a model of cell death in tripanosomátidos. The morphological changes, gragmentación DNA and analysis citométrico has allowed us to characterize the apoptosis-Like PCD in L.braziliensis. The second chapter examines the action Leishmanicida drug (platinum). It notes that the mechanisms of action of these molecules are related to platinum metal interactions with DNA and protein, structural and conformational changes of macromolecules Chapter Three focuses on the search and study of the conserved protein called poly (ADP - RIBOSA) polymerase (PARP), molecule modulating cell death. This protein has been described as a substrate of caspases in higher eukaryotes during death by apoptosis. Finally, the last chapter discusses the modulation of PARP and its possible application in the treatment against parasitic tripanosomátidos. Exhibiting and apply a new therapeutic strategy against tipanosomátidos based on the combination of compounds capable of damaging DNA and molecules capable of inhibiting cell repair. We have succeeded thus enhancing the activity of drugs Leishmanicidas.
  • PILOT STUDIES ON THE RELATIONSHIP PARASITO-HOSPEDADOR IN THE SYSTEM ECHINOSTOMA CAPRONI RICHARD, 1964 (TREMATODA: ECHINOSTOMATIDAE) -ROEDOR.

    Author: ESPERT FERNANDEZ ANA.
    Year: 2005.
    University: VALENCIA [More theses of this university] [www.uv.es].
    Place of defense: FACULTAD DE FARMACIA.
    Place of preparation: FACULTAD DE FARMACIA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#114022
    Summary: In the present work is deepening in relations parásito - hospedador used as experimental models E. Caproni-rata and E. Caproni-hámster. The course of infection by E. Caproni has been studied in both hosts from the biological point of view, pathological, immunological and proteomic, which has perfected a range of techniques: counting eggs, morphometry of me adult, Histologic, cell counts, immunohistochemistry, and indirect ELISA capture, electrophoresis on polyacrylamide gels in one and two dimensions, western-blot, and finally, amplification and cloning of genetic material from me. In hamster infections are chronic, unlike those produced in the rat, in which the adult worms are quickly expelled. In this sense, there is a higher percentage of establishment, fertility and growth of worms in infections hamster. Also, in hamster infection is characterized by intense local inflammatory response. In rats, there was an increase in cell mucosecretoras. The presence of serum antigen is related to the degree of bowel inflammation in each host. As for the humoral response, there is a greater systemic response in hamster that rat. This fact suggests that systemic responses are not crucial in the development and course of the infection. From the point of view proteomic noteworthy feature is the presence of enolasa, actin and GST in different extracts of E. Caproni as more proteins represented. Also discusses the possible involvement of Arab women in the establishment of the parasite. It can be concluded by noting that with this Labor reveals that the model Echinostoma-roedor can be a very useful experimental system for studying intestinal helminths. Keywords: Trematoda, Digenea, Echinostomatidae, Echinostoma, Echinostoma caproni, intestinal worm, hamster, rat, parásito - hospedador relationships, chronic infection, resistance, bowel pathology, humoral response, seroantígenos, coproantigens, immunoglobulin G, enolasa, actin, glutation- S-transferasa.
  • USING THE MULTI-PROTEIN CHIMERA OF LEISHMANIA INFANTUM IN INMUNPROFILAXIS AND DIAGNOSIS OF LEISHMANIASIS CANINE

    Author: CARCELÉN RODRÍGUEZ JESUALDO.
    Year: 2005.
    University: EXTREMADURA [More theses of this university] [www.unex.es].
    Place of defense: FACULTAD DE VETEROMAROA.
    Place of preparation: FACULTAD DE VETERINARIA - UNIVERSIDAD DE EXTREMADURA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#114868
    Summary: This paper focused first on the analysis dela capacity inmunoestimuladora of Protein Multicomponente Chimera (PQ) Lesihmania infantum and determining the best formulation in the dose, route of administration and adjuvants for this recombinant protein, identifying rates protectividad obtained with the challenge of experimental infection. It carried out various experiments that enabled canines know the effectiveness of these products as stimulators of the immune system. Once demonstrated the safety of these chemicals and the type of immune response induced studies protectividad generated once the dogs subjected to the challenge of experimental infection, demonstrated the validity of these trials for the development of vaccines against canine leishmaniasis . This work was also the subject of analysis Protein Chimera as reliable tool for the diagnosis of leishmaniosisi canine and the potential prognostic value of the results that can make use of the recombinant protein in the serodiagnosis of this emerging disease and rapidly expanding. As reflected in the objectives of this work the first part of the study focused on the analysis of the immunogenic and protective ability of certain recombinant antigens of the parasite. The experimental model (System Test) for the development of the survey was the canine species. The dogs used were 40 and came Service Animalario of the University of Extremadura. Such animals remained on the premises Service Animalario of the University, Campus Caceres, being the characteristics of the location and operation as described in the national and European legislation relating to the care and animal welfare (). Also these studies were developed plicando in all aspects of what has been described for compliance with the principles of Good Laboratory Practices (GLP) (OECD). The test substance was administered with different formulations, with the dose and route of administration indicated by the supplier. To accomplish our goals were conducted along the entire experience different studies Bipatológicos, through complete clinical examination of the animal study, analysis of biochemical and hematological parameters, urine, the proteinemia, among other studies Parasitológicos: qualitative and quantitative through crops System specific parasite; Immunologic Studies, through the analysis of the cellular and humoral immune response and Studies Anantomopatológicos and Histopatológicos of samples taken both in vivo and postmortem. The second part of this work focused on the analysis of the diagnostic efficacy of canine leishmaniasis of Protein Chimera. It used a large bank serums canines, in particular 142 sera from our records and clinical samples obtained frozen in Consula of Parasitology of Clinical Veterinary Hospital, School of Veterinary Medicine of Caceres. Through these sera were able to analyze and contrast 4 methods immunological diagnostics for the lesihmanioisis canine; on the one hand and the usual IFIs ELISA antigens totals and by the use of another protein Chimera of L.infantum by the method of micro - ELISA antigens total and on the other the use dela Protein Chimera of L.infantum by the method of micro-ELISA indirect and inmunocromatográfico.
  • THE EPIDEMIOLOGY AND THE BURDEN OF MALARIA IN MOZAMBIQUE.

    Author: MABUNDA SAMUEL JOSE ALVES.
    Year: 2006.
    University: BARCELONA [More theses of this university] [www.ub.es].
    Place of defense: FACULTAT DE MEDICINA.
    Place of preparation: FACULTAT DE MEDICINA.
    URL: http://www.kriptia.com/en/CIENCIAS_MEDICAS/PATOLOGIA/PARASITOLOGIA_HUMANA/1#121571
    Summary: Malaria is found primarily in tropical regions of the world, sub-Saharan Africa remains the most affected area. The high efficiency of the mosquito vector Anopheles gambiae complex and Anopheles funestus favors a wide transmission of Plasmodium falciparu, the parasite more predominant and most malignant of the species causing malaria. The local environmental conditions are appropriate transmission and often occurs along the whole year. The limited resources and the socio-economic instability are factors that hinder the full effectiveness of control strategies dela malaria. Data conservative estimate that the burden of this disease causing more than 300 million episodes of clinical and between 1-3 million deaths each year, with children the hardest hit. In Mozambique malaria is endemic throughout the country because of a multitude of factors such as climate / environments (favorable temperatures and precipitation patterns, ample spaces for breeding) and socioeconomic (poverty-related inadequate housing, media preventive unaffordable) -. The transmission is perennial, with peaks during and after the rainy season. The study carried out across the country between the years 2002 and 2003 was designed to determine the prevalence and intensity of infection by Plasmodium, the prevalence and severity of malaria in children under 10 years of age and pregnant women through different ecological niches, in order to characterize the intensity of malaria transmission and estimate the burden of this disease in Mozambique. The study involved house-to-house visit in 24 districts selected randomly. It included a total of 12, 002 individuals, both children under 10 years of age and pregnant women. The study malariométrico was to collect blood for puncture in the finger to prepare a thin layer thick and another to identify the species of parasite of malaria and an estimate of the density, and for determining the concentration of hemoglobin. It took the axillary temperature in the presence of fever and we performed enzyme test for the rapid diagnosis of malaria. The study consisted of entomological collection of mosquitoes sprayed with piretrum. Altogether 6557 mosquitoes anófeles female of 1440 houses were analyzed for sporozoite infection using PCR techniques, and the rate of inoculation entromológica was determined for each stratum across different regions. This comprehensive study throughout the country confirmed that malaria, especially that caused by Plasmodium falciparum, remains endemic across the country, and therefore represents a major public health problem in Mozambique. The transmission is due to sl Anopheles gambiae and Anopheles funestus. There is a substantial range in the intensity of malaria transmission through the various geographical and ecological niches of the country. This heterogeneity is reflected in the large variation in the prevalence of infection by Plasmodium falciparum, and partly as a consequence of changes in rates estimated entomological inoculation. Young children and pregnant women represent the group most susceptible to infection, and this means greater exposure to malaria.
6 theses in 1 pages: 1
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