PHOSPHORUS COMPOUNDS

Author: MARTÍN BARRAL ANA ISABEL.
Year: 2004.
University: COMPLUTENSE DE MADRID.
Place of defense: FACULTAD DE FARMACIA.
Place of preparation: FACULTAD DE FARMACIA.

Summary: In this paper have been obtained and characterized 3 glasses sol-gel with 25% in moles and CaO content SIO2 + P2O5: 75 +0; 72.5 + 2.5 and 70 +5, respectively. Has also been studied their behavior In vitro in a simulated body fluid, SBF.En glasses with phosphorus, this element binds to calcium forming small clusters crystal, which changes the properties of glass, both textual (specific surface increases and decreases the volume and pore diameter) and bioactivity in vitro (lower reactivity initial faster crystallization apatita). The bioactivity of the glass also has been evaluated in three additional protocols in vitro: SBF dynamic plasma inorganic carbonated simulated CSIP, and SBF enriched with albumin, SBF + alb.En dynamic layer obtained is thicker and the molar ratio Ca / P menor.En CSIP, crisalización of apatita accelerates but the layer is more delgada.En SBF + alb adsorption of albumin on the three glasses is almost instantaneous and difficulty crystallization of apathy. Crops have been conducted on rat osteoblast glasses before and after recubrirlos with a layer apatita.La biocompatibility of glass was good, increasing the phosphorus content, and very good of the glass coated apathy. Finally, there are hybrid orgánicos-inorgánicos adding PVAL the glass sol-gel.El PVAL facilitated obtaining monoliths, mientrasa that p2o5 difficult synthesis and reduced bioactividad.El increased PVAL and P2O5 increased degradation in vitro.En hybrids with further degradation was not formed apatita.Además, these hybrids can be used to obtain controlled porosity glass with the following thermal elimination of PVAL (Agent porógeno).

Author: PADILLA MONDÉJAR SUSSETTE.
Year: 2004.
University: COMPLUTENSE DE MADRID.
Place of defense: FACULTAD DE FARMACIA.
Place of preparation: FARMACIA.

Summary: This work focuses on the up-biocerámicas, both dense and porous using the gel-casting, as well as on obtaining bioactive materials made from blends of hidroxiapatira (HA) and a glass obtained by the sol-gel method. The method gel-cansting presents great advantages over the usual methods for shaping biocerámicas already yielding pieces with multiple forms and high dimensional accuracy as required clínicamente.Además bodies in green obtained show elevated properties mecánicas.En this work conducting a thorough study on factors affecting the stability of colloidal suspensions achieve concentrated HAS and mixtures thereof vidrido.Utilizando the suspension and by the method of gel-casting settle pieces dense and porosas.En latter two new routes used to generate porodsidad.Por elsewhere were prepared and characterized different materials made from blends of HA and glass, in order to obtain materials with greater bioactiviada of HA.Se changed both the content of glass as temperature heat treatment. The results showed the utilidasd method gel-casting to shape pieces tatno dense as porous different biocerámicas.Se have been able to establish the conditions for the preparation of concentrated suspensions and HA HA / vidrio.Se have gained a wide variety of materials different characteristics dependienndo of clinical requirements, obtaining material gain more bioactivity and readsormción that HA.Los methods used to obtain spare novel porous as they are designed to achieve a high interconnection and a pore size sufficient to permitri bone growth. Besides the pieces presented a dual porosity where besides pores in the order of 400 um there are other smaller pore size (1-2 um), which are important to enable the exchange of physiological fluids and disseminating fármacos.Las pieces thus obtained can be direct use as implant materials for the controlled release of drugs and as a support for cell growth in tissue engineering.